Better catch the moon’s disappearing act Tuesday — there won’t be another like it for three years.

The total lunar eclipse will be visible throughout North America in the predawn hours — the farther west, the better — and across Asia, Australia and the rest of the Pacific after sunset. As an extra treat, Uranus will be visible just a finger’s width above the moon, resembling a bright star.

Totality will last nearly 1 1/2 hours — from 5:16 a.m. to 6:42 a.m. EST — as Earth passes directly between the moon and sun.

Known as a blood moon, it will appear a reddish orange from the light of Earth’s sunsets and sunrises. At the peak of the eclipse, the moon will be 390,653 kilometers away, according to NASA scientists. Binoculars and telescopes will enhance viewing, provided the skies are clear.

South America will get a glimpse of Tuesday’s lunar eclipse, weather permitting. Striking out altogether, Africa, the Middle East and most of Europe will have to wait until 2025.

Among those providing a livestream of Tuesday’s lunar extravaganza: Griffith Observatory in Los Angeles and the Italian-based Virtual Telescope Project.

It’s the second total lunar eclipse this year; the first was in May. The next one won’t be until 2025. Plenty of partial lunar eclipses will be available in the meantime.
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When world leaders, diplomats, campaigners and scientists descend on Sharm el-Sheikh in Egypt for talks on tackling climate change, don’t expect them to part the Red Sea or other miracles that would make huge steps in curbing global warming.

Each year there are high hopes for the two-week United Nations climate gathering and, almost inevitably, disappointment when it doesn’t deliver another landmark pact like the one agreed 2015 in Paris.

But those were different days, marked by a spirit of cooperation between the world’s two biggest polluters — the United States and China — as well as a global realization that failure to reach an agreement would put humanity on a self-chosen track to oblivion.

This November the geopolitical tiles have shifted: a devastating war in Ukraine, skyrocketing energy and food prices, and growing enmity between the West on the one hand and Russia and China on the other make for difficult conditions at a gathering that requires cooperation and consensus.

“There’s a lot of high and low expectations around this Egypt COP, a lot of mix of ambition and fatalism,” said Avinash Persaud, special envoy for the Barbados prime minister.

Here’s what to look out for during the 27th Conference of the Parties, or COP27, from Nov. 6-18 and why it might still end up being a success.

Science warnings

Scientists are more concerned about global warming than three decades ago, when governments first came together to discuss the problem because the pace of warming in the past decade is 33% faster than in the 1990s.

Greenhouse gas emissions are still rising, while tangible impacts from climate change are already being felt around the world.

But there is some progress. Before Paris, the world was heading for 4.5 degrees Celsius of warming by the end of the century compared to pre-industrial times.

Recent forecasts have that down to 2.6 C, thanks to measures taken or firm commitments governments have already made. That’s far above the 1.5 C limit countries agreed to seven years ago, however, and the time for keeping that target is fast running out.

Researchers say the world has already warmed by 1.2 C and capping temperatures at 1.5 C would require emissions to drop by 43% by the end of the decade, a highly ambitious goal. To get to the less ambitious 2 C goal emissions have to fall 27%.

“The 1.5 degrees is in intensive care and the machines are shaking. So, it is in high danger. But it is still possible,” United Nations Secretary-General Antonio Guterres said. “My objective in Egypt is to make sure that we gather enough political will to make this possibility really moving forward, to make the machines work … We’re getting close to moments where tipping points might, at a certain moment, make it irreversibly impossible to achieve. Let’s avoid it at all costs.”

Energy scramble

Prices for oil, coal and natural gas have jumped since Russia’s invasion of Ukraine. Some countries have responded by trying to tap new sources of fossil fuel.

This has raised concerns about governments backsliding on their commitments to cut emissions, including the agreement at last year’s climate talks to “phase down” the use of coal and sharply reduce the amount of methane — a powerful greenhouse gas — released into the atmosphere.

At the same time, rising fossil fuel prices have made renewable energy more competitive. Building solar and wind power plants remains more expensive for developing countries though. To help them cut their emissions quickly, rich nations are negotiating aid projects known as ‘just transition energy partnerships’, or JET-Ps, with several major emerging economies including Indonesia and India that could be finalized during or shortly after COP27.

Climate finance

One of the big sticking points in past negotiations concerned the financial support poor countries receive from rich nations to cope with climate change.

A deadline to provide $100 billion annually by 2020 was missed and now looks set to be achieved only next year. Future funding needs are likely to be in the trillions, not billions, said Mohamed Nasr, Egypt’s lead negotiator.

“The gap on finance is huge,” he said, noting that half the population of Africa doesn’t yet have access to electricity, much less clean energy.

Developed countries including the United States have also yet to make good on a pledge to double the amount they provide for adaptation, and make that half of the overall funding.

Discussions on climate finance also include the highly contentious issue of countries being compensated for the irreparable harm they’ve suffered as a result of global warming. Big polluters have strongly opposed demands for ‘loss and damage’ payments in the past, but observers say they’ve seen a softening of positions recently, including by the United States.

“I think that people are not expecting miracles in terms of a huge fund just miraculously appearing, but they are expecting a credible, meaningful pathway,” said Inger Andersen, head of the U.N. Environment Programme.

This would give countries that have done very little to cause the climate crisis but are on the front line of dealing with it “something to hold on to,” she said.

Activist voices

Swedish climate activist Greta Thunberg is not coming to this year’s gathering and recently called the U.N. process a “scam.”

Other activists have also voiced frustration at the slow pace of negotiations, given the scale of the threat posed by climate change. But Harjeet Singh of Climate Action Network International said there is no other space where all countries are equal.

“Tuvalu theoretically is as powerful as the U.S. and Malawi as powerful as the European Union,” he said of the talks. “For us as civil society it’s also a place to call out these countries, to call their bluff, to put a spotlight on those polluters and raise our voices.”

University of Maryland social scientist Dana Fisher, who studies the environmental movement, said given Egypt’s authoritarian government and an escalation of in-your-face tactics by frustrated protestors, especially youth, she would not be surprised if there are clashes.

“There’s going to be a vanguard of them who are going to be willing to break the law and engage in probably what will start out as civil disobedience, peaceful civil disobedience,” Fisher said. “And they’re probably going to get beaten up. And it’s going to be very good for mobilizing sympathizers.”

Egypt has insisted that campaigners will have “full opportunity of participation, of activism, of demonstration, of voicing that opinion.”

Eye on Africa

The gathering in Egypt will be the first time since 2016 that U.N. climate talks have taken place in Africa. Experts say it is important the continent gets more attention, given how heavily it is affected by rising temperatures.

“If we look at the 50 countries that are most vulnerable to climate change impacts and who have the least resilience, these are low income countries and most of them are in Africa,” said Preety Bhandari of the World Resources Institute. “So it is fortuitous that we are having this particular COP in Africa to highlight what the vulnerable countries are asking from the climate regime.”

Campaigners say that recognizing the challenges Africa faces and prioritizing the needs of vulnerable countries is essential for a successful outcome this year.
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World health officials are linking a significant rise in African Ebola outbreaks in this century to climate change.    

Uganda’s September 20 Ebola outbreak is just the latest in a growing number of eruptions of this deadly hemorrhagic disease in Africa. Since 2000, the World Health Organization has reported 32 outbreaks of Ebola, 19 in the last decade compared to 13 in the preceding one.

Ebola is one of a range of zoonotic diseases — infections originating in animals and jumping to humans. A WHO analysis finds Ebola and other viral hemorrhagic fevers constitute nearly 70% of these outbreaks. The remaining 30% include dengue fever, anthrax, plague, and monkeypox.  

WHO Africa incident manager for the Ebola outbreak in Uganda, Patrick Otim, says the number of zoonotic diseases occurring in the region in the last decade has increased by more than 63%.

“There have been a couple of researchers that have shown a possible link between the climatic changes that we are seeing and the increase in zoonotic diseases, and for this particular case for Ebola, for instance,” he said.

Otim said diseases are caused by several factors. Ebola, he said, is strongly influenced by the human factor. As populations increase and people encroach on wildlife habitats, interaction with animals increases. This, he said, increases the spread of disease to humans.

Otim said temperature and climatic changes also spur migration and movement of some Ebola virus hosts. 

“For the Ebola virus, we know that the bats and other animals are hosts of this particular virus,” he said. So, when they move from areas where, for instance, there is drought or whether areas that are no longer conducive for them and they move to favorable areas, they may move into an area where the human population is inhabiting and therefore the interaction between the humans increases.”

WHO says Ebola now has spread to seven districts in Uganda beyond the original epicenter in the Mubende district. The latest reports put the number of cases at 131, including 48 deaths.

The current Ebola outbreak in Uganda has been triggered by the so-called Sudan strain for which there is no vaccine. WHO said several promising candidate vaccines soon will undergo clinical trials to evaluate their potential against Ebola.
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Astronomers have discovered the closest known black hole to Earth, just 1,600 light-years away.

Scientists reported Friday that this black hole is 10 times more massive than our sun. And it’s three times closer than the previous record-holder.

It was identified by observing the motion of its companion star, which orbits the black hole at about the same distance as Earth orbits the sun.

The black hole was initially identified using the European Space Agency’s Gaia spacecraft, said Kareem El-Badry of the Harvard-Smithsonian Center for Astrophysics.

El-Badry and his team followed up with the International Gemini Observatory in Hawaii to confirm their findings, which were published in Monthly Notices of the Royal Astronomical Society.

The researchers are uncertain how the system formed in the Milky Way. Named Gaia BH1, it’s located in the constellation Ophiuchus, the serpent-bearer.
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More than 120 world leaders will attend this year’s U.N. climate talks, and requests by environmental activists to stage a rally during the event would be responded to “positively,” host Egypt said.

Veteran diplomat Wael Aboulmagd, who heads the Egyptian delegation, told reporters Friday that his country had been working for months to set the scene for “meaningful outcomes” at the two-week meeting in the Red Sea coastal resort of Sharm el-Sheikh starting Sunday.

“We have, I think about 121 maybe, and the number is growing, heads of state and government here,” he said during an online briefing. “We hope that it will be a watershed moment.” Leaders such as U.S. President Joe Biden and British Prime Minister Rishi Sunak confirmed their attendance, but Aboulmagd said other major heads of state such as China’s Xi Jinping and India’s Narendra Modi would not be going.

Aboulmagd said recent scientific reports highlighted the urgency of tackling global warming.

“Everyone is now aware of the gravity of the situation, of the enormity of the challenge, and have come here hopefully to work together,” he said.

Greenhouse gases, financial aid

Several thorny issues will be discussed at the November 6-18 talks, including further cutting greenhouse gas emissions and boosting financial aid for poor countries struggling with the impacts of climate change. It is the first such meeting held in Africa since 2016. Over 40,000 people have registered for the event.

Aboulmagd appealed to negotiators to engage constructively. “We cannot afford to waste any time,” he said. “So everyone must rise to the occasion and must move away from the adversarial winner-takes-all approach that has plagued this process for too long.”

Civil society groups have expressed concern that their presence at this year’s talks will be restricted, citing Egypt’s questionable human rights record.

But Aboulmagd said activists would get their space, with special arrangements already put in place “for those who want to organize demonstrations or protests or stand-ins.”

Asked about the possibility of holding a large rally midway through the talks, as has traditionally happened in previous meetings, he said, “That will be taken care of.”

Organizers would need to submit the names of contact persons, and city officials must approve the planned route.

“Once a request to that effect comes, it will be responded to positively,” he said.

Egypt would press diplomats to live up to the lofty pledges their leaders had made, Aboulmagd said, warning that so far, these had not been translated into the negotiating rooms.

“This separation between the reality in the public sphere and what actually happens in negotiating rooms cannot continue,” he said. “It is about real lives that are being lost and future lives that will be devastated” by unchecked climate change. 
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The lone volunteer in a study involving a gene-editing technique has died, and those behind the trial are now trying to figure out what killed him.

Terry Horgan, a 27-year-old who had Duchenne muscular dystrophy, died last month, according to Cure Rare Disease, a Connecticut-based nonprofit founded by his brother, Rich, to try and save him from the fatal condition.

Although little is known about how he died, his death occurred during one of the first studies to test a gene editing treatment built for one person. It’s raising questions about the overall prospect of such therapies, which have buoyed hopes among many families facing rare and devastating diseases.

“This whole notion that we can do designer genetic therapies is, I would say, uncertain,” said Arthur Caplan, a medical ethicist at New York University who is not involved in the study. “We are out on the far edge of experimentation.”

The early-stage safety study was sponsored by the nonprofit, led by Dr. Brenda Wong at the University of Massachusetts Chan Medical School and approved by the Food and Drug Administration. The hope was to use a gene-editing tool called CRISPR to treat Horgan’s form of Duchenne muscular dystrophy. The rare, genetic muscle-wasting disease is caused by a mutation in the gene needed to produce a protein called dystrophin. Most people with Duchenne die from lung or heart issues caused by it.

At this point, it’s unclear whether Horgan received the treatment and whether CRISPR, other aspects of the study or the disease itself contributed to his death. Deaths are not unheard of in clinical trials, which test experimental treatments and sometimes involve very sick people.

But trials involving CRISPR are relatively new. And Fyodor Urnov, a CRISPR expert at the Innovative Genomics Institute at University of California, Berkeley, said any death during a gene therapy trial is an opportunity for the field to have a reckoning.

“Step one is to grieve for the passing of a brave human soul who agreed to be basically a participant in an experiment on a human being,” Urnov said. “But then, to the extent that we can, we must learn as much as we can to carve out a path forward.”

Few answers yet

A statement from Cure Rare Disease said multiple teams across the country are looking into the details of the trial and its outcome, and the company intends to share findings with the scientific community.

“It will probably be 3-4 months to come up with a full conclusion,” said spokesman Scott Bauman. “At this stage of the game, saying anything is pure speculation.”

The company, which is also working on 18 other therapeutics, said in its statement that the team’s work is essential not only to shed light on the study’s outcome but also “on the challenges of gene therapy broadly.” Meanwhile, it said, “we will continue to work with our researchers, collaborators, and partners to develop therapies for the neuromuscular diseases in our pipeline.”

Bauman said the company has filed a report on death the with the FDA as required. The FDA declined to release or confirm the report.

Sarah Willey, spokesperson for Chan Medical School, said scientists there provided data to the company for the report. She later emailed to say no one there would comment further; out of respect for the family’s wishes, all information would come from Cure Rare Disease.

A crucial question is whether CRISPR played a part in Horgan’s death.

The chemical tool can be used to “edit” genes by making cuts or substitutions in DNA. The tool has transformed genetic research and sparked the development of dozens of experimental therapies. The inventors of the tool won a Nobel Prize in 2020.

In this case, scientists used a modified form of CRISPR to increase the activity of a gene. The CRISPR therapeutic is inserted directly into the body and delivered to cells with a virus.

But CRISPR is not perfect.

“We know that CRISPR can miss its target. We know that CRISPR can be partially effective. And we also know that there may be issues with … viral vectors” that deliver the therapy into the body, Caplan said. “Red flags are flying here.”

Another difference? The recent trial involved just one person — a type of trial Caplan is skeptical about.

A ‘medical pioneer’

On the company’s website, Horgan was described as a “medical pioneer” who “will be remembered as a hero.”

In 2020, the Montour Falls, New York resident blogged that he was diagnosed with Duchenne at age 3. As a kid, he said, he loved computers — once building his own — and would play catch in the driveway with his family when he could still walk. Later in his life, he used a motorized wheelchair. He studied information science at Cornell University and went on to work at the school in the information science department.

“As I grew up and began to understand what it meant to have DMD, my fears about this disease began to grow as it began to manifest,” Horgan wrote. “There weren’t many, or any, trials available to me through the years” — until this one brought the prospect of a customized drug.

The plan was to suppress Horgan’s immune system to prep his body for a one-time, gene-editing therapy delivered by IV at UMass medical school, followed by monitoring in the hospital. The therapy is designed to increase the level of an alternate form of the dystrophin protein using CRISPR, with the goal of stabilizing or potentially reversing the progression of symptoms.

Urnov, scientific director for technology and translation at the Berkeley genomics institute, said no other trial targeted this disease using this kind of virus to deliver this particular payload with its modified form of CRISPR.
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The U.S. flu season is off to an unusually fast start, adding to an autumn mix of viruses that have been filling hospitals and doctors’ waiting rooms.

Reports of flu are already high in 17 states, and the hospitalization rate hasn’t been this high this early since the 2009 swine flu pandemic, according to the Centers for Disease Control and Prevention. So far, there have been an estimated 730 flu deaths, including at least two children.

The winter flu season usually ramps up in December or January.

“We are seeing more cases than we would expect at this time,” the CDC’s Dr. José Romero said Friday.

A busy flu season is not unexpected. The nation saw two mild seasons during the COVID-19 pandemic, and experts have worried that flu might come back strong as a COVID-weary public has moved away from masks and other measures that tamp the spread of respiratory viruses.

Community Montessori school in New Albany, Indiana, switched to virtual teaching at the end of the week because so many students were out sick with the flu. Beginning Monday, the school’s 500 students will go back to wearing masks.

“Everybody just wants kids on campus, that is for sure,” said the school’s director, Burke Fondren. “We will do what we need to do.”

There may be some good news: COVID-19 cases have been trending downward and leveled off in the past three weeks, Romero said.

And in a few parts of the country, health officials think they may be seeing early signs that a wave of another respiratory virus may be starting to wane. RSV, or respiratory syncytial virus, is a common cause in kids of cold-like symptoms such as runny nose, cough and fever. While RSV continues to rise nationally, preliminary data suggest a decline in the Southeast, Southwest and in an area that includes Rocky Mountain states and the Dakotas, CDC officials said.

Experts think infections from RSV increased recently because children are more vulnerable now, no longer sheltered from common bugs as they were during pandemic lockdowns. Also, the virus, which usually affects children ages 1 and 2, is now sickening more kids up to age 5.

At the University of Chicago Medicine Comer Children’s Hospital, beds have been full for 54 days straight.

“The curves are all going up for RSV and influenza,” said Dr. John Cunningham, Comer’s physician-in-chief.

RSV illnesses seem to be unusually severe, he added.

Comer has had to turn down transfer requests from other hospitals because there was no room. Chicago-area hospitals had been able to transfer kids to Missouri, Iowa and Wisconsin, but that’s stopped.

“They have no more beds, either,” Cunningham said.

There’s not yet a vaccine against RSV, but there are shots for flu and COVID-19. Health officials say flu vaccinations are down in both kids and adults compared with before the pandemic, although they are up in children from last year.

So far this season, there have been an estimated 1.6 million flu illnesses and 13,000 hospitalizations. Flu activity is most intense in some of the areas where RSV is fading, including the Southeast, according to CDC data.
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U.S. pharmaceutical company Pfizer and its German partner BioNTech said Friday a new study indicates their COVID-19 booster vaccination provides significant antibody protection against the omicron variant and its subvariants among adults.

The companies introduced a new booster targeting the omicron variant in September, and U.S. Food and Drug Administration (FDA) approved it for use last month, along with a similar vaccine produced by U.S. drug company Moderna, as have several other countries.

In their statement, the companies said the new data show the COVID-19 booster, adapted to target the omicron BA.4 and BA.5 subvariants, generated four times the neutralizing antibodies against the omicron variants among adults ages 55 and older than their original vaccine.

The study also showed after one month, the booster dose generated more than 13 times the number of neutralizing antibodies against the variants in patients older than 55 than patients who received the original vaccine; 9.5 times the antibodies in patients 18 to 55 years old.

Pfizer Chairman and Chief Executive Officer Albert Bourla said in the statement that as the United States heads into the holiday season, the new data should encourage people who have not done so to seek out a booster shot as soon as they are eligible to receive it — six months after their last vaccination.

Pfizer and BioNTech said they have shared the data with the FDA and plan to share it with the European Medicines Agency and other global health authorities as soon as possible.

A booster dose of the omicron-targeting vaccine has been authorized by the FDA for emergency use for ages 5 years and older and has also been granted marketing authorization in the EU by the European Commission.

Some information for this report came from The Associated Press and Reuters.
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Australia can expect another wave of COVID-19 infections in coming weeks, according to experts, as new variants circulate. Coronavirus cases are rising quickly in New South Wales and Victoria, Australia’s most populous states.

The World Health Organization declared COVID-19 a global pandemic on March 11, 2020. The declaration is still active.

In Australia, life is resembling what it was before the virus. Most disease-control measures, such as mandatory mask-wearing on public transport and self-isolation for people testing positive to COVID-19, have been scrapped. Some restrictions, however, still apply to health, disability and aged-care facilities.

Public health authorities in the states of New South Wales and Victoria have warned that another surge in infections is approaching. Official data has shown that in the last week of October, coronavirus case numbers increased in all Australian states and territories except Queensland.

There were 9,707 positive diagnoses in the week ending Oct. 29 in New South Wales, an 11% increase from the previous week.

Government data has shown that more than 95% of Australians over 16 have had at least two doses of a COVID-19 vaccine.

In a video posted on Twitter on Thursday, New South Wales Chief Health Officer Kerry Chant warned of a spike in infections.

“By looking at all the local information we have and what is happening overseas we believe COVID cases will rise in the coming weeks,” Chant said. “The protection the New South Wales community has from vaccination and previous infection continues to reduce the risk of severe illness. However, the elderly and those with underlying health conditions will continue to be at higher risk.”

COVID-19 continues to spread in other countries.

China’s COVID-19 cases hit their highest in 2½ months Thursday, according to health authorities. The world’s most populous nation is following President Xi Jinping’s zero-COVID policy, which has seen millions of people locked down in major cities. The WHO has said China has had more than 9 million confirmed coronavirus cases since the pandemic began.

In the United States, White House chief medical adviser Dr. Anthony Fauci said Thursday that new omicron variants were gaining ground across the country as winter approaches.

Researchers at University College London say Britain could be relatively free of COVID-19 this Christmas but potentially faces another wave of cases in January.

The European Centre for Disease Prevention and Control has said COVID-19 variants BQ.1 and BQ.1.1 are likely to drive up cases in the months ahead in Europe.

As of Thursday, there have been more 628 million confirmed COVID-19 cases globally, including about 6.5 million deaths reported to the WHO.

Isolation has helped to protect some communities from the virus. The WHO said that Niue, a small island in the South Pacific Ocean with a population of 2,000, has recorded 85 COVID-19 cases and no fatalities during the pandemic.
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