In labs across the United States, scientists are working on innovative tests using animals and insects to detect cancer earlier. As VOA’s Dora Mekouar reports, recent research suggests bees and dogs can sniff out the disease sooner than machines can.
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London — Two new cases of the mpox variant clade 1b detected in the U.K. are the first locally transmitted cases in Europe and the first outside Africa, the World Health Organization said Tuesday.

The U.K. Health Security Agency (UKHSA) confirmed late Monday that the two new cases were household contacts of Britain’s first case identified last week, bringing the country’s total confirmed cases to three.

The WHO warned that European states should be prepared for “rapid action” to contain the latest mpox variant, which spreads through close physical contact including sexual relations and sharing closed spaces.

The two cases are also the first to be locally transmitted outside Africa since August 2024, when the WHO declared the outbreak of the new variant an international public health emergency — its highest level of alarm.

Those affected are under specialist care and the risk to the U.K. population “remains low,” UKHSA said.

The original case was detected after the person traveled to several African countries on holiday and returned to the U.K. on Oct. 21.

The patient developed flu-like symptoms more than 24 hours later and, on Oct. 24, started to develop a rash that worsened in the following days.

Mpox, a viral disease related to smallpox, has two types, clade 1 and clade 2. Symptoms include fever, a skin rash or pus-filled blisters, swollen lymph nodes and body aches.

The WHO first declared an international public health emergency in 2022 over the spread of clade 2. That outbreak mostly affected gay and bisexual men in Europe and the United States.

Vaccination and awareness drives in many countries helped stem the number of worldwide cases and the WHO lifted the emergency in May 2023 after reporting 140 deaths out of around 87,400 cases.

In 2024, a two-pronged epidemic of clade 1 and clade 1b, a new strain that affects children, has spread widely in the Democratic Republic of Congo.

The new strain has also been recorded in neighboring Burundi, Kenya, Rwanda and Uganda, with imported cases in Sweden, India, Thailand, Germany and the U.K.
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Geneva — The World Health Organization on Tuesday listed 17 pathogens that cause widespread disease and death, including HIV, malaria and tuberculosis, for which it said new vaccines were “urgently needed.”

The U.N. health agency said that it with its list was providing the first global effort to systematically prioritize endemic pathogens based on criteria including disease burdens, antimicrobial resistance risk and the socioeconomic impact.

“We need to do this because we would like to shift the focus from developing vaccines away from commercial returns towards regional and global health needs,” Mateusz Hasso-Agopsowicz, a WHO vaccine specialist, told reporters in Geneva via video link from Poland.

The study reconfirms longstanding priorities for vaccine research and development, including HIV, malaria and tuberculosis — three diseases that collectively kill nearly 2.5 million people each year, WHO said.

But it also identifies lesser-known pathogens as top disease control priorities, highlighting the urgency to develop new vaccines for pathogens that are becoming increasingly resistant to antimicrobials.

Among them was Group A streptococcus, which causes severe infections and contributes to some 280,000 deaths from rheumatic heart disease each year, mainly in lower-income countries.

Ita also highlights the dangers of Klebsiella pneumoniae — a bacterium that is responsible for around 40% of neonatal deaths due to blood infection, or sepsis, in low-income countries.

These vaccines “would not only significantly reduce diseases that greatly impact communities today but also reduce the medical costs that families and health systems face,” WHO vaccine chief Kate O’Brien said in a statement.

Vaccines for the various pathogens listed are at different stages of development, WHO said, with some like ones for HIV, Group A streptococcus and hepatitis C virus still at the research stage. 

Others, like ones for dengue and tuberculosis, have been developed and are approaching regulatory approval or introduction.

Hasso-Agopsowicz explained that the 17 listed pathogens were wreaking the most havoc in lower-income countries, explaining why more progress has not been made previously on developing vaccines against them.

“What typically has happened in the past is that vaccine research and development has been influenced by profitability of new vaccines. What that means is that diseases that severely affect low-income regions unfortunately receive much less attention,” he said.

With the new list, he said, “we want to change the focus… so that the new vaccine research and development is driven by health burden and not just commercial opportunities.”
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geneva — World Health Organization member countries resumed negotiations Monday to finalize an agreement on pandemic prevention, with outbreaks of mpox, Marburg and H5N1 stressing the urgency of reaching an agreement without repeating the deadly mistakes of COVID-19.

After more than two years of negotiations, there is hope of reaching an agreement in the next 15 days, especially since the negotiators have agreed to postpone discussions on the most contentious points: the sharing of knowledge and equitable access to medical advances.

Recent negotiations at COP16 in Colombia on biodiversity, which provided for a comparable mechanism, stumbled on this point.

WHO chief Tedros Adhanom Ghebreyesus stressed the need to balance timeliness and workable deal.

“Time is not our friend,” Tedros told national negotiators at the opening of the talks. “COVID is still circulating. Mpox is a global health emergency. We have a Marburg outbreak and H5N1 spreading. The next pandemic will not wait.”

Never again

In December 2021, fearing a repeat of the catastrophe caused by COVID-19, which killed millions of people, the 194 member countries of WHO agreed to reach an agreement on pandemic prevention, preparedness and response.

The emergence of a new strain of mpox, the deadly Marburg virus outbreak in Rwanda and the spread of H5N1 avian flu in recent months have clarified the issues.

Diplomats have agreed on most of the draft’s 37 articles during 11 rounds of negotiations.

The main section on which consensus will need to be found concerns access to pathogens for the scientific community and medical research, and then to products to combat the pandemic such as vaccines or other tests derived from this research.

In order not to block everything, the idea is to postpone the discussion on the details of the pathogen access and benefit sharing system (PABS) until later.

Battle for fairness

For the moment, there is an impasse between rich and poor countries, which have not forgotten that they were abandoned to their fate during the COVID-19 pandemic.

“If the world has failed on one thing, it is on the issue of equity” during the COVID-19 pandemic, the head of WHO stressed on Friday.

“Africa was left behind at the time, and this should not happen,” Tedros said.

‘Bitter taste’

Helen Clark, former New Zealand Prime Minister, believes that “the South sees the North as protecting its pharmaceutical industries,” and this “has left an incredibly bitter taste between the North and the South.”

The International Federation of Pharmaceutical Manufacturers and Associations called for an agreement “allowing the private sector to innovate.”

“Intellectual property must be respected, and technology transfer must always be voluntary and on mutually agreed terms,” the federation insisted.

Among the country representatives, Malaysia, speaking on behalf of a group of developing countries known as the Equity Group, said “major improvements are still desperately needed in many areas.”

It demanded that at least 20% of real-time production of vaccines, tests and treatments go to developing countries.

Tanzania, on behalf of 48 African countries, said it could not “accept an agreement not based on equity.”

The Indonesian negotiator said an agreement that only preserves the status quo is unacceptable, because “empty promises will not save lives.”

China insisted that “quality should not be sacrificed for time.”

Germany’s representative called for an acceleration of the talks to “focus on what is achievable.”
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CALI, Colombia — Wealthy nations appeared to hit a limit with how much they are willing to pay to conserve nature around the world, instead shifting their focus at the two-week U.N. biodiversity summit toward discussions of private money filling the funding gap.

At the COP16 negotiations in Cali, Colombia, countries failed to figure out how they would mobilize $200 billion annually in conservation funding by 2030, including $30 billion that would come directly from rich nations.

That money, pledged two years ago as part of the landmark Kunming-Montreal Global Biodiversity Framework agreement, is meant to finance activities that boost nature, such as sustainable farming or patrolling wildlife reserves.

But there was no consensus as talks dragged on beyond the summit’s scheduled end on Friday, during which dozens of delegations departed. By Saturday morning’s roll call, there was no longer a quorum among the nearly 200 nations for an agreement to pass, forcing organizers to abruptly suspend the meeting.

“I am both saddened and enraged by the non-outcome of COP16,” said Shilps Gautam, chief executive of project finance firm Opna.

“The wild thing about the nature financing discussions is that the numbers discussed are already a pittance.”

Human activities such as farming, mining, and urban development are increasingly pushing nature into crisis, with 1 million or so plant and animal species thought to be at risk of extinction.

Climate change, a result of fossil fuel burning, is also adding to nature’s woes by raising temperatures and disrupting weather cycles.

Countries will meet again in Azerbaijan next week for the U.N.’s COP29 climate summit, which again will be focused on the steep need for funding from wealthy nations to their poorer counterparts to help shoulder climate costs.

Little money from rich nations

Even before the talks broke down, developed nations had signaled an unwillingness to offer large amounts of cash.

European governments including Germany and the Netherlands have slashed their foreign aid budgets over the last year, while France and the U.K. are also cutting back.

Government development money specifically targeted at nature conservation abroad fell to $3.8 billion in 2022 compared with $4.6 billion in 2015, according to the Organization for Economic Co-operation and Development.

At COP16, U.N. Secretary General Antonio Guterres demanded that countries make significant new contributions to the Global Biodiversity Framework Fund.

The response was muted. Nations at COP16 pledged $163 million in contributions to the fund, bringing total contributions to roughly $400 million – far from a major contribution to the $30 billion target from nations by 2030.

The United States, which is not a party to U.N. Convention on Biological Diversity, has not contributed.

“The public money is already leveraged as much as we can,” Florika Fink-Hooijer, the European Union’s director general of environment, told reporters at the summit.

“We now have to look at other sources of funding.”

Private cash

When it came to going after private capital, delegates at the COP16 summit agreed to a plan to charge pharmaceutical and other companies for their use of genetic information in the research and development of new commercial products.

Pharmaceutical companies Pfizer, Merck, AstraZeneca and Land Sanofi did not respond to request for comment on the deal.

Experts estimate the plan could generate about $1 billion annually.

That still doesn’t cover the billions needed to halt the collapse of ecosystems, like the Amazon rainforest or coral reefs. The world will need to devise ways for enticing private investment in nature-friendly projects, said Marcos Neto, director of global policy at the U.N. Development Program.

Some tools include green bonds or debt-for-nature swaps, whereby countries refinance their debt at lower interest rates in order to spend the savings on conservation. The World Economic Forum estimates that debt-for-nature swaps could generate $100 billion in nature funding.
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Goma, Congo — Some health officials say mpox cases in Congo appear to be “stabilizing” — a possible sign that the main epidemic for which the World Health Organization made a global emergency declaration in August might be on the decline.  

In recent weeks, Congo has reported about 200 to 300 lab-confirmed mpox cases every week, according to WHO. That’s down from nearly 400 cases a week in July. The decline is also apparent in Kamituga, the mining city in the eastern part of Congo where the new, more infectious variant of mpox first emerged.  

But the U.N. health agency acknowledged Friday that only 40% to 50% of suspected infections in Congo were being tested — and that the virus is continuing to spread in some parts of the country and elsewhere, including Uganda.  

While doctors are encouraged by the drop in infections in some parts of Congo, it’s still not clear what kinds of physical contact is driving the outbreak. Health experts are also frustrated by the low number of vaccine doses the central African nation has received — 265,000 — and say that delivering the vaccine to where it’s needed in the sprawling country is proving difficult. WHO estimates 50,000 people have been immunized in Congo, which has a population of 110 million.  

Scientists also say there needs to be an urgent, broader vaccination effort for the entire continent to halt mpox’s spread and avoid further worrisome genetic mutations, like the one detected earlier this year in Congo after months of low-level circulation.  

“If we miss this opportunity, the likelihood of another significant outbreak increases substantially,” said Dr. Zakary Rhissa, who heads operations in Congo for the charity Alima.  

So far this year, there have been roughly 43,000 suspected cases in Africa and more than 1,000 people have died, mostly in Congo.  

“We’ve seen how past outbreaks, such as the one in Nigeria in 2017, can lead to larger global events if not effectively contained,” he said. The 2017 epidemic ended up leading to the 2022 global outbreak of mpox that affected more than 100 countries.  

Rhissa said the decline in cases in Kamituga — where mpox initially spread among sex workers and miners — is an opening to put more programs in place for vaccination, surveillance and education.  

Georgette Hamuli, an 18-year-old sex worker, hadn’t been aware of mpox until immunization teams arrived last week in the poor neighborhood where she works in Goma, the biggest city in eastern Congo.  

“They told us we’re highly exposed to the risk of infection,” she said. “We insist on condoms with our clients, but some refuse … if they don’t want to use a condom, they double the amount they pay.”  

Hamuli said she and other friends who are sex workers each received 2,000 Congolese francs ($0.70) from a charity to get vaccinated against mpox — but it wasn’t the money that swayed her. 

“The vaccine is also necessary,” she said. “I think we’re now protected.”   

The Africa Centers for Disease Control and Prevention has estimated Congo needs at least 3 million mpox vaccines to stop the virus, and another 7 million for the rest of Africa. So far, WHO and partners have allocated 900,000 vaccines to nine African countries affected by mpox and expect 6 million vaccines to be available by the end of this year.  

Mpox epidemics in Burundi, Kenya, Rwanda and Uganda had their origins in Congo, and a number of cases in travelers have also been identified in Sweden, Thailand, Germany, India and Britain.  

Fewer than half of the people who are most at risk in Congo have been vaccinated, according to Heather Kerr, Congo director for the International Rescue Committee.  

“We only have a tiny amount of vaccines, and nothing for the kids,” she said.  

The vaccines for Congo are largely coming from donor countries like the U.S and through UNICEF, which mainly uses taxpayer money to buy the shots.  

“We’re getting a charitable approach where we only see very small donations of vaccines to Africa,” said Dr. Chris Beyrer, director of the Global Health Institute at Duke University. “What we need is a public health approach where we immunize populations at scale.”  

Drugmaker Bavarian Nordic, which makes the most widely used mpox vaccine, said it would sell shots destined for Africa at the lowest price possible.  

The advocacy group Public Citizen estimated UNICEF paid $65 per dose of the Jynneos mpox vaccine made by Bavarian Nordic, far higher than nearly all other vaccines used in public health programs. 

Dr. Salim Abdool Karim, an infectious diseases expert at South Africa’s University of KwaZulu-Natal, said mpox outbreaks typically peak and disappear quickly because of how the virus spreads. This time, however, he said there are two complicating factors: the virus’ transmission via sex and the continued spillover from infected animals.  

“We’re in new territory with mpox this time,” he added. “But we’re never going to solve this until we vaccinate most of our people.” 
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KARACHI — Unprecedented air pollution levels in Pakistan’s second-largest city of Lahore prompted authorities to take emergency measures on Sunday, including issuing work-from-home mandates and closing primary schools.  

The city held the top spot on a real-time list of the world’s most polluted cities on Sunday after recording its highest ever pollution reading of 1900 near the Pakistan-India border on Saturday, based on data released by the provincial government and Swiss group IQAir.  

The government has shut primary schools for a week, advising parents to ensure children wear masks, said Senior Minister of Punjab Marriyum Aurangzeb during a press conference, as a thick blanket of smog enveloped the city.  

Citizens have been urged to stay indoors, keep doors and windows shut, and avoid unnecessary travel, she said, adding that hospitals had been given smog counters.  

To reduce vehicle pollution, 50% of office employees would work from home, said Aurangzeb.  

The government has also imposed a ban on three-wheelers known as rickshaws and halted construction in certain areas to reduce the pollution levels. Factories and construction sites failing to comply with these regulations could be shut down, she said.  

Aurangzeb described the situation as “unexpected” and attributed the deterioration in air quality to winds carrying pollution from neighboring India.   

“This cannot be solved without talks with India,” she said, adding the provincial government would initiate talks with its bigger neighbor through Pakistan’s foreign ministry.   

The smog crisis in Lahore, similar to the situation in India’s capital Delhi, tends to worsen during cooler months due to temperature inversion trapping pollution closer to the ground.  
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RENO, Nevada — Conservationists and a Native American tribe are suing the U.S. to try to block a Nevada lithium mine they say will drive an endangered desert wildflower to extinction, disrupt groundwater flows and threaten cultural resources.

The Center for Biological Diversity promised the court battle a week ago when the U.S. Interior Department approved Ioneer Ltd.’s Rhyolite Ridge lithium-boron mine at the only place Tiehm’s buckwheat is known to exist in the world, near the California line halfway between Reno and Las Vegas.

It is the latest in a series of legal fights over projects President Joe Biden’s administration is pushing under his clean energy agenda intended to cut reliance on fossil fuels, in part by increasing the production of lithium to make electric vehicle batteries and solar panels.

The new lawsuit says the Interior Department’s approval of the mine marks a dramatic about-face by U.S. wildlife experts who warned nearly two years ago that Tiehm’s buckwheat was “in danger of extinction now” when they listed it as an endangered species in December 2022.

“One cannot save the planet from climate change while simultaneously destroying biodiversity,” said Fermina Stevens, director of the Western Shoshone Defense Project, which joined the center in the lawsuit filed Thursday in federal court in Reno.

“The use of minerals, whether for EVs or solar panels, does not justify this disregard for Indigenous cultural areas and keystone environmental laws,” said John Hadder, director of the Great Basin Resource Watch, another co-plaintiff.

Rita Henderson, spokesperson for Interior’s Bureau of Land Management in Reno, said Friday the agency had no immediate comment.

Ioneer Vice President Chad Yeftich said the Australia-based mining company intends to intervene on behalf of the U.S. and “vigorously defend” approval of the project, “which was based on its careful and thorough permitting process.”

“We are confident that the BLM will prevail,” Yeftich said. He added that he doesn’t expect the lawsuit will postpone plans to begin construction next year.

The lawsuit says the mine will harm sites sacred to the Western Shoshone people. That includes Cave Spring, a natural spring less than 1.6 kilometers away described as “a site of intergenerational transmission of cultural and spiritual knowledge.”

But it centers on alleged violations of the Endangered Species Act. It details the Fish and Wildlife Service’s departure from the dire picture it painted earlier of threats to the 15-centimeter-tall wildflower with cream or yellow blooms bordering the open-pit mine Ioneer plans to dig. 

The mine’s permit anticipates up to one-fifth of the nearly 3.6 square kilometers the agency designated as critical habitat surrounding the plants — home to various pollinators important to their survival — would be lost for decades, some permanently.

When proposing protection of the 368 hectares of critical habitat, the service said “this unit is essential to the conservation and recovery of Tiehm’s buckwheat.” The agency formalized the designation when it listed the plant in December 2022, dismissing the alternative of less-stringent threatened status.

“We find that a threatened species status is not appropriate because the threats are severe and imminent, and Tiehm’s buckwheat is in danger of extinction now, as opposed to likely to become endangered in the future,” the agency concluded.

The lawsuit also discloses for the first time that the plant’s population, numbering fewer than 30,000 in the government’s latest estimates, has suffered additional losses since August that were not considered in the U.S. Fish and Wildlife Service’s biological opinion.

The damage is similar to what the bureau concluded was caused by rodents eating the plants in a 2020 incident that reduced the population as much as 60%, the lawsuit says.

The Fish and Wildlife Service said in its August biological opinion that while the project “will result in the long-term disturbance (approximately 23 years) of 146 acres (59 hectares) of the plant community … and the permanent loss of 45 acres (18 hectares), we do not expect the adverse effects to appreciably diminish the value of critical habitat as a whole.” 
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The good news: You will get a glorious extra hour of sleep. The bad: It’ll be dark by late afternoon for the next few months in the United States.

Daylight saving time ends at 2 a.m. local time Sunday, which means you should set your clock back an hour before you go to bed. Standard time will last until March 9, when we will again “spring forward” with the return of daylight saving time. 

“Fall back” should be easier. But it still may take a while to adjust your sleep habits, not to mention the downsides of leaving work in the dark or trying to exercise while there’s still enough light. Some people with seasonal affective disorder, a type of depression usually linked to the shorter days and less sunlight of fall and winter, may struggle, too. 

Some health groups, including the American Medical Association and American Academy of Sleep Medicine, have said it’s time to do away with time switches and that sticking with standard time aligns better with the sun — and human biology. 

Two states — Arizona and Hawaii — don’t change and stay on standard time. 

Here’s what to know about the twice-yearly ritual. 

How the body reacts to light 

The brain has a master clock that is set by exposure to sunlight and darkness. This circadian rhythm is a roughly 24-hour cycle that determines when we become sleepy and when we’re more alert. The patterns change with age, one reason that early-to-rise youngsters evolve into hard-to-wake teens. 

Morning light resets the rhythm. By evening, levels of a hormone called melatonin begin to surge, triggering drowsiness. Too much light in the evening — that extra hour from daylight saving time — delays that surge and the cycle gets out of sync. 

How do time changes affect sleep? 

Even an hour change on the clock can throw off sleep schedules — because even though the clocks change, work and school start times stay the same. 

That’s a problem because so many people are already sleep deprived. About 1 in 3 U.S. adults sleep less than the recommended seven-plus hours nightly, and more than half of U.S. teens don’t get the recommended eight-plus hours on weeknights. 

How to prepare for the time change 

Some people try to prepare for a time change jolt by changing their bedtimes little by little in the days before the change. There are ways to ease the adjustment, including getting more sunshine to help reset your circadian rhythm for healthful sleep. 
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